1. No category

E[F QJZS N[ \KRGKR[G \KRG[BZ FTKRP
\KRVGD \GNKTV KGCKZG \GKZGNY \NE FRGH\ OT OK[RC Z[BM ,\KRVGD
.Z\GK ZIGBP NKDC ZGHIPF NNM LZEC TKVGK
FIMGF ,KTCJ GB KJ\RKS ZGYPP OKRDGSYB OKRGPZGFN FVK[IF
,ZGHIPF OGKS ZIBN KVKNI KNBRGPZGF NGVKJC [GPK[F KCDN \RMGSPM
OKKNBRGPZGF OKNGVKJC [GPK[ KCDN FM ET \RMGSPM FIMGF BN LB
GPDEGF Z\GKC OK[EIF \GZGEFP QGKZF \TKRPN \GNGND OD .QGKZVN
[KDEFN [K LMKVN .E[F QJZSN K\GFP Z\K QGMKS KZSIM FRGZIBN
,KVKNI KNBRGPZGF NGVKJC CIZR [GPK[P TRPKFN LZGXF \B EIGKPC
.FHM NGVKJN \GZGZC \GKGG\F \GPKKY Z[BM JTPN
OK[R KCDN GZ\GB[ OKRG[F QGMKSF KPZGD OB QKJGNIN ZGZC BN
ZGVKS N[C ZCDGP QGMKSC \GBXPRF OK[R KCDN OD OKRGMR NKDZ QGMKSC
.E[F QJZSN OKRDC \GKXJGP N[ \GKB[R GB QJZS N[ K\IV[P
QKC QGMKSF KPZGD \TV[FC QGKPEC \GRGZIBF OKR[C \MPG\ \GZVSF
\GMKBC OKZYIPC QKKET IMGF BN ZCEF LB \GRG[F \GXGCYF
.FFGCD \KDGNGKPEKVB
F\GNKTKN OKR[ ZVSP FHP \RICR \K\VGZ\ \KRG[BZ FTKRP
EGTC .FGCD QGMKSC OK[RC E[F QJZSC FBGNI\N QGMKSF \EZGFC
QJZSC FBGNI\ \GEKZGPM GIMGF QVKSYGNZG QVKSYGPJ GPM \GVGZ\[
\BHM FEKZK KM FIMGF QKKET QKB ,\KNNMF QGMKSF \KKSGNMGBC E[F
QDC \GKXJGP N[ \GKB[RC BN EIGKPCG ,\GKB[R OK[RC \PKKY
\GK\KKTC KBGGN \GTVG\ N[ FZG[ GNB \GVGZ\N [K LEKBP .BRCA1
.\GBKZC OK[RC NGVKJC KGBZ \GIKJC IGGJ \ZKP[C ZCGEP[M
\KRGKR[ FTKRP
FPNIFF \NGMK \B ZV[N ETGKP QJZS N[ OEYGPF KGNKDF
GRINXF BN QNXB[ OK[R N[ OKKIF \GMKB \B OD GPM ,\GEZ[KFFG
\T NMC \GSV\R QJZS \TKRPN \GNGTV QMN .E[C N[PN ,QJZS TGRPN
E[F QJZS N[ OEYGPF KGNKDN .OEYGP KGNKDN \GNGTV KRV NT \GVKETM
TGXKC KBR\C FNIPFP F\GP\F \EZGFC IMGPG K\KPB LZT [K
\EZGFC FNKTKM FIMGF FKVZDGPPF \YKEC .OKK\GMKBG OKREVY
.ZGHIPF OGKS CN[C \GBXPR[ OK[RC GB ,50 NKD NTP OK[RC F\GP\F
\GZKTX OK[RC FKVZDGPP K"T OEYGPF KGNKDF \GNKTKN FIMGF QKB
GPM \GJK[ \GNKTKN FIMGF QKBG NKDZ QGMKSC \GBXPRF 50 NKDP
\YKEC GB E[F N[ \KPXT FYKEC ,BVGZ K"T E[ \YKEC
.NKD NMC KCKJYVB OEYGP KGNKDC (\KNGY NT FYKEC) ERGBS=FZJNGB
E[ QJZS KGNKD \NGMK \NTCM FRGZIBN FPDEGF E[F N[ MRI \YKEC
\GKJRD \GNY\ \B[GRF OK[RF \XGCYC FKVZDGPP N[ GHP FFGCD
OB ZGZC BN .GNB OK[RN \GBKZCF EZ[P K"T FZKYS \YKECM FZ[GBG
QRKB[ FGCD QGMKSC OK[RC FKVZDGPPF N[ GHN NTP \NTG\ GH FYKECN
.BRCA OKRDC \GNY\ \GB[GR
.OKR[ FZ[T [PIM FHP KVZDGPP KGNKD LZTP NTGV NBZ[K \RKEPC
OK[RF \KKSGNMGB NNM N[ \K\JK[ FYKZS \KRMG\C NIGF 1996 \R[C
QJZS KGNKDN \KPGBNF \KRMG\F \NTVFG OGHKK QGPKH NNGMF 74=50 NKDC
NM \GMKB \ZYCG \KXZBF \GNKTVF ZGJKR F\GKZIBC[ E[F
QP FBC \KRMG\N FPHGKF .FH B[GRN OKZG[YF OKKRKNYF OKMKNF\F
CGXY\ .\GBKZCF EZ[P OTJP \NTVGP BKFG QJZSC FPINPN FEGDBF
NBZ[KC FYKECN \GRTKFF .QJZSC FPINPN FEGDBFP TKDP \KRMG\F
\GRTKF \PGTN ,\GNKTV \GR[ 8 ZIBN 60% =MN FTKDPG \KSIK FMGPR
E[F QJZS
JZRZ KED 'VGZV
,FKDGNGKPEKVBG FNKFYF \BGVZN 'IPF NFRP
FVKI ,"NPZM" KBGVZF HMZPF
NT TKCXP \GCZ ZYIP \GR[ LZGBN ZCJXF[ KDGNGKPEKVBF TEKPF
OKK[KB \GDFR\F KSGVE K"T \PZDRF FNIP GRKF ,GZYKTC ,E[F QJZS[
NCGYP .\GKVKXVS \GKJRD \GNY\ N[C \PZDRF FNIP ,QJYF GYNICG
QJZSF KZYP NNMP 10%=MC FZK[KF \KJRDF FTV[FF \B EGPBN
N[ K\IV[P ZGVKS OKKY QJZSC \GNGIF NNMP [KN[MN ET KM QKKXNG
N[ \GIMGR OB ZGZC BN .\ZIB GB \BHM FCZKY \DZEC E[F QJZS
UG\K[ NT FTKCXP ,\GKVKXVS \GKXJGP KGFKHN ZCTP ,K\IV[P ZGVKS
QKC \GRG[ \GVK[IN UGDF \CGD\C KJRD QGKPE NT GB QGMKS KPZGD N[
.FIV[PF \GRC
F\VXR I\V\PF GB I\GVPF ONGTF \GRKEP CGZC[ FECGTF
NT FTKCXP E[F QJZSC \GNGIF ZGTK[C \ZMKR FKKNT OKR[F LZGBN
DGFR .GH FNIP N[ FKDGNGKJBC \GDFR\F KPZGD N[ KHMZPF OGYPF
\KRDGERBF \KNBRGPZGFF FVK[IF KPGI\N OKZYPF CGZ \B SIKKN
FEKNF NKDC ,ZGHIPF OGKSG \NKI\ NKDC KGJKC KEKN OKBC[ KVM
GPM) \KRDGSYBF GB ,EGTG OKENKF ZVSPC ,FYRFF KSGVEC ,FRG[BZF
FRGH\ EIGKPCG FRGH\ N[ OKJRPNB OD Z[BM (KVKNI KNBRGPZGF NGVKJ
KZGNY QHBPG \KRVGD \GNKTV QMG \GYZK \ZK\T FRGH\ GB QPG[ \ZK\T
OHKNGCJPF NT O\TV[F LZE ZYKTC KBEGN CGZY OKNTGV ,NNGM
[GCK[ BGF CN \PG[\ LKZXPF KZ[VB QGMKS OZGD .KNBRGPZGFF
"DN=J'D"N FVK[ICG \GZP[PC FEGCTC ZG[YF ,QKRGJNPF OHKNGCJP
.UGDC QKPF KRGPZGF \GPZN ZG[Y \GKFN KG[T GN[ FNGTVF QGRDRP OD[
\GDFR\F SGVE \GFHN Q\KR BN E[F QJZS \GNGI \KCZPCG ZIBP
QKC FKXYBZJRKBN FNGED \GTP[P [K KM KBEGN CGZY ,JNGC KDGNG\V
NNM LZEC BJC\PF ,GRVGDC KJRDF JSYJRGYF QKCN \GDFR\FF KSGVE
GB (CYPs) FRG[BZF FHBVF KPKHRB \GNKTV N[ \KJRDF FZYCC
QGYK\ N[ OKRGRDRP QMG (GST =G NAT GPM) FKKR[F FHBVF KPKHRB
.DNA
\KRG[BZ FTKRP
NMM ,E[F QJZSC \GNIN QGMKSF NT TKV[FN Q\KR K[TP QVGBC
KKGRK[ ,\KRVGDF \GNKTVF \ZCDFN FMZEFG \GCZT\F K"T ,FBZRF
OKZPGI OFCG OKCKNXPF \IV[PP \GYZK N[ FMKZXF \ZCDFG FRGH\
GPM) FECTP KBR\C OKKRBPGF E[ QJZS KB\ EDRM \NGMK GPKDEF[
QHBPF ZGVK[ LG\ ,(OKJRBKX=GK\=GHKBG OKRGK\=NGK\=KE ,OKNGERKB
.FRP[FP \GTRPKFG NNGMF KZGNYF
FYRF N[ K\GTP[P QDP EKYV\ NT TKCXPF CZ TEKP OD OKKY
FH JYVSB [KDEFN GRKNT FCGI QMNG E[F QJZSN QGMKSF \EZGFC
.ZGCKXN
NKD[ OG[P TKV[FN Z\GK F[Y OKZIB KNBRGPZGF QGMKS KSGVE NT
SGVEP YNIM ONGTC OGKM OKTCYR OKENK ZVSPG QG[BZ QGKZF
\NI\F NKD .G\GR[N OK[R BKCFN F[YKG NNGM \K\ZCI \GDFR\F
\GNKTVG FRGH\ KSGVEN Z\KF QKC OKZG[Y ZGHIP OGKS NKDG ZGHIP
FPC
8
2. Bruce J. Trock, Leena Hilakivi-Clarke, Robert Clarke. MetaAnalysis of Soy Intake and Breast Cancer Risk J Natl Cancer
Inst 2006;98:459 71
3. Leslie Bernstein, Alpa V. Patel, Giske Ursin, Jane SullivanHalley, Michael F. Press, Dennis Deapen, Jesse A. Berlin,
Janet R. Daling, Jill A. McDonald, Sandra A. Norman,
Kathleen E. Malone, Brian L. Strom, Jonathan Liff, Suzanne
G. Folger, Michael S. Simon, Ronald T. Burkman, Polly A.
Marchbanks, Linda K. Weiss, Robert Spirtas. Lifetime
Recreational Exercise Activity and Breast Cancer Risk
Among Black Women and White Women J Natl Cancer
Inst 2005;97:1671 9.
\MZTPC OKZGP[ \GZGYPF ZB[
\GKRMG\ \NTVF \NKI\ OT ZCM \GCZ \GKCZTP \GRKEPC 80% 70=M N[
K\VGY\ QVGBC FYKECF TGXKC NT FEVYFC BGF USGR K[GY .FYKZSF
NT \GEKVYP QRKB FYKECF \B \GTXCPF OK[RFP \GCZ .[ZERM
\GYKECF QKC LMP OKNGED OKZTV \IK\V .OKK\R[N \IB FTGXKC
.\PBC OEYGP CN[C OKNGEKD \GFHN KGMKSF \B \K\GTP[P FRKJYP
1000 =M FR[ KEP FNDPG FKRVC FCKXF[ KGNKDF KETKC \EPGT \KRMG\F
\KCZP .OKEK[IP OKPGJVPKS QFN QKB[ OK[RC ,E[C \GKGZKBPP
.\KSIK OEYGP CN[C \GND\P \GKGZKBPPF
\GZGYP
1. Aman U. Buzdar. Dietary Modification and Risk of
Breast Cancer. JAMA 2006;295:691-2
OKNGIFG OKBKZCF ZGCKX QTPN = QJZSC FPINPN FEGDB
F
\GNIPC YCBPF \B FNKCGP BKF ,HBP .1952 \R[C FPYGF ,NBZ[KC Z\GKC FNGEDF \K\GCER\FF F\GPTF ,QJZSC FPINPN FEGDBF
.NBZ[KC QJZSP F\GP\FG FBGNI\F \B \KIVFN FZJPC \G\KHIF NMC \NTGVG NBZ[KC QJZSF
QMNG FRG[BZF FDZEF QP KPGBN ETK FGGFP QJZSF \NIP OT \GEEGP\FF .NBZ[K \RKEPC ZGCKXF NNMN TDGR QJZSF \NIPC YCBPF
QJZS KNGI 120,000= M NBZ[KC OKKI ,OGKM .OKNGIG OKBKZC = ZGCKXF NNMN \GKJRGGNZG \GCG[I QJZSC FPINPN FEGDBF \GKGNKTV
\PK[NG ZYIPF OGEKYN \GEGF LB ,OK[EI QJZS KNGI 23,500= M WZBC OKVSGR FR[ KEP[ OKBZP OKRG\RF .CYTPC GB NGVKJC OKBXPRF
\GMKBC ZMKR ZGVK[G FNIPF QP OKBVZRF OK[RBF ZVSPC K\GTP[P NGEKD NI ,NGVKJFG OEYGPF KGNKDF ,QGICBF KTXPB ZGVK[ NT [DE
.OKNVGJPF N[ OFKKI
N[ NGTV\FG ZM[F \GBXGF .GF[NM K\N[PP EZ[P CKXY\P QGPKP BNNG ZGCKXF \GPGZ\N \GEGF \Z[VB\P FEGDBF \GNKTV
.EIBM KPGBN=QKCG KPGBN FEKP FRYC QGKXN FKGBZF FECGT ,K\R[F FCKXY\ NM LSP ECNC 10%= M \GGFP QJZSC FPINPN FEGDBF
E[F QJZS
FPC 10